: Ramifications of CYP2C19 Genotype on Outcomes of Clopidogrel Treatment Clopidogrel.

Conversely, carriers of the ultrarapid enzyme activity allele *17 possess an elevated platelet response to clopidogrel and an increased threat of bleeding .6 However, observational analyses that usually do not include untreated controls may be confounded by other elements. For example, the same genetic marker may possess pleiotropic effects, which influence the rate of metabolism of drugs other than clopidogrel, or may have an effect on outcomes through independent mechanisms such as linkage disequilibrium with various other close by CYP genes .Time, B.M., B.Ch., Nobert Peshu, M.B., Ch.B., Kevin Marsh, F.R.C.P., Kathryn Maitland, M.D., Ph.D., J. Anthony Scott, F.R.C.P., Thomas N. Williams, M.D., Ph.D., James A. Berkley, F.R.C.P.C.H., Sian Floyd, M.Sc., Nelson L.S. Tang, F.R.C.P.A., Paul E.M. Great, Ph.D., Denise L.M. Goh, M.R.C.P.C.H., and Adrian V.S. Hill, F.R.C.P., D.M.: CISH and Susceptibility to Infectious Diseases Tuberculosis, malaria, and invasive bacterial disease together account for more than 5 million deaths annually in the developing globe. Although a substantial proportion of interindividual variation in disease susceptibility can be attributed to environmental factors such as malnutrition and contamination with the human being immunodeficiency virus , a substantial part is unexplained.