A pioneer in understanding the p53 tumor suppressor pathway.
Their landmark research published in Technology in 1989 determined a p53 transactivation domain and demonstrated that p53 mutants didn’t activate transcription, paving the way for important discoveries regarding its mechanism in the development of numerous cancers including breast, colon, lung and ovarian cancer. Her subsequent analysis provided the necessary mouse versions to validate the vital gatekeeper role the proteins Mdm2 takes on in regulating p53 activity, and also establishing the need for dual features of p53 in preventing tumor advancement where it not merely forces cell death, but also halts a defective cell's capability to reproduce and helps maintain genomic balance.AMCP Chief Executive Officer Edith A. Rosato, RPh, IOM, issued the following declaration: We support HHS’s initiatives to expand prescription medication monitoring applications and real-time data sharing, as well concerning better integrate info into electronic health information among medical researchers. AMCP would encourage HHS to proceed even further by allowing health plans and other appropriate managed care stakeholders to have access to this information within a coordinated effort to help patients and decrease the burden of opioid-related overdoses and dependency. Beyond HHS’s proposal latest, AMCP urges passage of legislation that would allow Medicare Part D and Medicare Advantage prescription drug plans to limit sufferers with a history of abuse to a single prescriber and/or pharmacy , comparable from what occurs in the personal marketplace and the Medicaid program already.